Researchers at the University of Texas Health Science Center have found that the use of metformin among older men has a positive effect on a range of age-related cancers, heart disease, depression, dementia and mortality rates.
The scientists analysed data from 41,204 men aged over 65 with type 2 diabetes and found, among the 8,393 who were using metformin to manage their diabetes, an association with a reduction in age-related diseases. The effect was particularly high in men classified as being at high-risk of certain diseases.
“The effect of metformin on reducing a specific occurrence was the greatest in the class with the highest risk for that condition (eg, the greatest reduction in CVD was found in the high CVD risk class), and these benefits appeared to further reduce mortality,”
said Chen-Pin Wang, PhD, of the department of epidemiology and biostatistics at the University of Texas Health Science Center at San Antonio.
While the research is exiting Chen-Pin Wang said that using metformin for co-morbidity prevention requires further investigation but added the study provided important data for future trials.